After becoming infected, Baker attempted to warn Snake of the virus upon deducing the cause of his sudden heart attack, but was unable to before drawing his last breath. Baker had some awareness of FOXDIE's development, but did not anticipate that it would actually be deployed. This was carried out in order to eliminate both the terrorists and anyone else involved on Shadow Moses, and to allow recovery of the hijacked Metal Gear REX, dummy warhead data, and the bodies of the Genome Soldiers, intact. The virus was programmed to kill the renegade members of FOXHOUND, who had taken over the island's nuclear disposal facility, as well as ArmsTech President Kenneth Baker. In February 2005, the Pentagon ordered Naomi to inject FOXDIE into an unassuming Solid Snake, shortly before his mission to Shadow Moses Island. Shadow Moses Incident Main article: Shadow Moses Incident Since then, the virus had been altered and recreated several times. When the virus was successfully engineered, it was Naomi who named it FOXDIE. The FOXDIE virus had been in development as the research hit a wall until 2003 when Dr. The FOXDIE project was led by the DIA operative Richard Ames under the authority of President George Sears, and under orders of the Patriots. The idea for a weapon that could eliminate specific individuals by targeting genes, was conceived by Patriot founder Zero as early as 1976, in response to the Philosophers' "ethnic cleansing" vocal cord parasites, which he deemed obsolete. The development of the FOXDIE virus was one of the Pentagon's biological weapons programs. Metal Gear Solid 4: Guns of the Patriots Review In addition, a vaccine was rumored to exist to evade the virus entirely. This is evidenced by how Psycho Mantis and Sniper Wolf, respectively, were able to avoid being affected by FOXDIE prior to death. Targets who use anti-anxiety medications such as pentazemin excessively may see the progression of the virus be significantly delayed in its manifestation. Older infected targets will see manifestation of FOXDIE much more rapidly than the young.įOXDIE cannot bypass the protective barriers in the lungs, rendering it non-airborne. The only difference between this and natural heart attacks is that the latter occur when the heart cells die from lack of oxygen and sugar, usually caused by a blocked coronary artery, rather than TNF-ε-induced apoptosis. The TNF-ε is carried along with the blood, to the heart, where it binds to the TNF receptors, causing apoptosis in myocardial cells, which in turn leads to the victim suffering a fatal heart attack. Once this genetic material is integrated into the host cell chromosome, it promotes TNF (tumor necrosis factor) epsilon production in the host. The FOXDIE virus enters macrophages in the target's bloodstream, then uses enzymes (integrase, primarily) to integrate its genetic material into a DNA sequence that it has been "programmed" to recognize (this last part being the difference between it and an ordinary retrovirus, which may display a tendency to integrate at certain sites but cannot be "programmed" to target specific sequences exclusively).
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